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Substitution preferences:
All protein types:
Favoured | Glu ( 2) | Arg ( 1) | Lys ( 1) | |||||
Neutral | Asp ( 0) | Met ( 0) | His ( 0) | Asn ( 0) | Ser ( 0) | |||
Disfavoured | Pro (-1) | Thr (-1) | Tyr (-1) | Ala (-1) | Trp (-2) | Leu (-2) | Gly (-2) | Val (-2) |
Ile (-3) | Phe (-3) | Cys (-3) |
Favoured | Glu ( 1) | |||||||
Neutral | Ala ( 0) | Asp ( 0) | Pro ( 0) | Gly ( 0) | His ( 0) | Asn ( 0) | Lys ( 0) | Met ( 0) |
Arg ( 0) | Ser ( 0) | Thr ( 0) | ||||||
Disfavoured | Val (-1) | Tyr (-1) | Leu (-1) | Phe (-2) | Cys (-2) | Trp (-2) | Ile (-2) |
Favoured | ||||||||
Neutral | Pro ( 0) | Asp ( 0) | Glu ( 0) | Asn ( 0) | Gly ( 0) | His ( 0) | Met ( 0) | Lys ( 0) |
Arg ( 0) | Ser ( 0) | Thr ( 0) | Val ( 0) | Ala ( 0) | ||||
Disfavoured | Leu (-1) | Trp (-1) | Tyr (-1) | Ile (-1) | Phe (-2) | Cys (-5) |
Favoured | His ( 7) | Glu ( 7) | Lys ( 6) | Arg ( 5) | Asn ( 3) | Asp ( 2) | ||
Neutral | Pro ( 0) | Tyr ( 0) | Trp ( 0) | |||||
Disfavoured | Ser (-1) | Ala (-2) | Met (-2) | Gly (-2) | Thr (-2) | Leu (-2) | Cys (-3) | Val (-4) |
Phe (-4) | Ile (-4) |
Role in structure: Being polar, Glutamine prefers generally to be on the surface of proteins, exposed to an aqueous environment.
Role in function: Glutamines are quite frequently involved in protein active or binding sites. The polar side-chain is good for interactions with other polar or charged atoms.